INSULT KASALLIGIDA SEREBROVASKULAR AUTOREGULATSIYA BUZILISHI: XAVF OMILLARINING MOLEKULYAR DETERMINANTLARI VA PROFILAKTIKANING PATOGENETIK ASOSLARI
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insult, serebrovaskular autoregulatsiya, endotelial disfunktsiya, ishemiya, neyroproteksiya, birlamchi profilaktika, aterotromboz.Abstrak
Insult global nevrologik nogironlik va o'lim sabablarining yetakchisi sifatida hozirgi kunda ham yetarli darajada oldi olinmayotgan kasallik bo'lib qolmoqda. Ushbu tezisda serebrovaskular autoregulatsiya mexanizmlari va uning buzilishi asosida rivojlanuvchi ishemik hamda gemorragik insult patogenezi molekulyar darajada tahlil qilinadi. Arterial gipertenziya, endotelial disfunktsiya va koagulyatsiya kaskadi buzilishlarining o'zaro aloqasi ko'rsatiladi. Birlamchi profilaktikada renin-angiotenzin tizimini maqsadli modulyatsiya qilish va trombosit agregatsiyasini boshqarishning klinik ahamiyati bayon etiladi.
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