5-(2-AMINOFENIL)-1,3,4-OKSADIAZOL-2-TIOLNING YANGI S-ALKIL HOSILALARI SINTEZI, TUZILISHI VA ANTIMIKROB FAOLLIGI

Authors

  • Jololiddinov Fazliddin Yo’ldoshali O’g’li Qo‘qon universiteti Andijon filiali, Biologik kimyo va farmatseftika kafedrasi o’qtuvchisi Author
  • Kamoldinov Salohiddin Sharobiddin o’g’li Qo’qon Universiteti Andijon filiali Tibbiyot fakulteti Davolash ishi yo’nalishi 2-bosqich talabasi Author

DOI:

https://doi.org/10.5281/zenodo.20507576

Abstract

Hozirgi kunda yuqumli kasalliklarni davolashda patogen mikroorganizmlarning ko‘p sonli antibiotiklarga rezistentligi (chidamliligi) global sog‘liqni saqlash tizimining eng jiddiy muammolaridan biridir [1]. Shu sababli, medicinal kimyoda yangi kimyoviy skafoldlar asosida samarali antimikrob va antifungal agentlarni ishlab chiqish o‘ta dolzarb hisoblanadi [2]. Benzimidazol va tiadiazol yadrolari bilan bir qatorda, tarkibida kislorod va azot saqlovchi 1,3,4-oksadiazol halqasi o‘zining past toksikligi hamda biologik nishonlar bilan vodorod bog‘lari hosil qila olish qobiliyati tufayli yuqori farmakoforlik potensialiga ega [3]. Xususan, oksadiazol halqasining 2-holatidagi ekzotsiklik tiol (–SH) guruhining selektiv S-alkillanishi molekulaning lipofillik xossasini oshiradi, bu esa uning hujayra membranalaridan oson o‘tib, faollikning kuchayishiga olib keladi [4, 5].

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Published

2026-06-02

Issue

Vol. 4 No. 50 (2026)

Section

Articles

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Copyright (c) 2026 Innovative Academy RSC

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Jololiddinov, F., & Kamoldinov, S. (2026). 5-(2-AMINOFENIL)-1,3,4-OKSADIAZOL-2-TIOLNING YANGI S-ALKIL HOSILALARI SINTEZI, TUZILISHI VA ANTIMIKROB FAOLLIGI. Science and Innovation, 4(50), 74-76. https://doi.org/10.5281/zenodo.20507576
Innovative Academy RSC
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