Статьи

O‘SIMLIK XOMASHYOSIDAN AJRATIB OLINGAN BIOLOGIK FAOL FLAVONOIDLAR KOMPLEKSINI MODIFIKATSIYALASH VA ULARNING VIRUSLARGA QARSHI FAOLLIGINI IN SILICO HAMDA IN VITRO USULLARDA BAHOLASH

Том 4 № 66 (2026) 117-119

2026-07-22 Статьи CC BY 4.0 Open Access

Авторы

  • Jamoliddinov Ma’rufjon Muhammad oʻgʻli Namangan viloyati Namangan tumani ixtisoslashgan maktab kimyo fani oʻqituvchisi

Аннотация

Ushbu ilmiy tezisda Glycyrrhiza glabra L. va Sophora japonica L. o‘simlik xomashyosidan ajratib olingan flavonoidlar majmuasini (ksantoxumol, kversetin, rutin) kimyoviy modifikatsiyalash va ularning viruslarga qarshi faolligini kompleks baholash natijalari keltirilgan. Flavonoidlar strukturasi yarim sintetik asillash hamda glikozillash reaksiyalari orqali o‘zgartirilib, ularning biofoydalanish darajasi va fermentativ retsipiyentlar bilan bog‘lanish afilligi oshirildi. In silico molekulyar doking tahlillari yordamida hosilalarning Gripp A (H1N1) neyraminidazasi hamda SARS-CoV-2 Mpro proteazasi bilan bog‘lanish energiyalari (ΔG) hisoblab chiqildi. In vitro tajribalarida Vero E6 va MDCK hujayra kulturalarida birikmalarning sitotoksikligi (CC50) va ingibirlash konsentratsiyasi (IC50) aniqlanib, terapevtik indekslari (TI) hisoblandi. Olingan natijalar modifikatsiyalangan flavonoid hosilalarining virus ingibitorlari sifatida yuqori samaradorlikka ega ekanligini tasdiqlaydi.

Ключевые слова:

Flavonoidlar modifikatsiya in silico molekulyar doking in vitro antivirual faollik neyraminidaza SARS-CoV-2 Mpro Vero E6 terapevtik indeks.

Библиографические ссылки

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Zakaryan, H., et al. (2017). Flavonoids: promising antiviral agents against acute respiratory infections. Archives of Virology, 162(9), 2539-2551.

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География читателей

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    Опубликован

    2026-07-22

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    Том 4 № 66 (2026)

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    Copyright (c) 2026 Innovative Academy RSC

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    Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.

    Как цитировать

    Jamoliddinov, M. (2026). O‘SIMLIK XOMASHYOSIDAN AJRATIB OLINGAN BIOLOGIK FAOL FLAVONOIDLAR KOMPLEKSINI MODIFIKATSIYALASH VA ULARNING VIRUSLARGA QARSHI FAOLLIGINI IN SILICO HAMDA IN VITRO USULLARDA BAHOLASH. Наука и инновации, 4(66), 117-119. https://www.in-academy.uz/index.php/SI/article/view/54923
    Innovative Academy RSC
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