ВЛИЯНИЕ ОСТРОГО СТРЕССА НА МОРФОЛОГИЧЕСКУЮ СТРУКТУРУ МОЗЖЕЧКА
Article Sidebar
Main Article Content
Abstract:
В работе рассматривается влияние острого стрессового воздействия на морфологическую структуру мозжечка. Актуальность исследования обусловлена расширением представлений о функциональной роли мозжечка, который, помимо участия в координации движений, вовлечён в регуляцию когнитивных и аффективных процессов. Целью исследования явился анализ морфологических изменений мозжечка, возникающих под воздействием острого стресса, с использованием гистологических и морфометрических методов. В ходе исследования были изучены количественные и качественные характеристики нейронов и глиальных клеток, а также особенности микроциркуляторного русла различных слоев мозжечка у экспериментальных животных. Полученные результаты показали статистически значимые изменения в плотности и морфологии клеток Пуркинье, а также в объемных характеристиках зернистого и молекулярного слоев мозжечковой коры. Выявленные структурные перестройки могут быть обусловлены воздействием стрессовых гормонов, нейроиммунными реакциями и изменениями в экспрессии генов, участвующих в стресс-ответе. Наблюдались также изменения дендритной структуры нейронов, что свидетельствует о перестройке синаптических связей и модификации нейропластичности.
Article Details
How to Cite:
References:
Gheorghe DA, Panouillères M, Walsh N. Psychosocial stress affects the acquisition of cerebellar-dependent sensorimotor adaptation. Psychoneuroendocrinology [Internet]. 2018 Mar 27 [cited 2025 Oct];92:41. Available from: https://doi.org/10.1016/j.psyneuen.2018.03.013
Melka N, Pszczolińska A, Klejbor I, Moryś J. The cerebellum: the ‘little’ brain and its big role. Folia Morphologica [Internet]. Via Medica; 2024 Jul 2 [cited 2025 Oct]; Available from: https://doi.org/10.5603/fm.93251
Ohinska NV, Небесна ЗМ, Крамар С. Modern ideas about morphological changes in the cerebellar cortex under influence of factors of different origin. Journal of Education Health and Sport [Internet]. 2020 Feb 28 [cited 2025 Sep];10(2):368. Available from: https://doi.org/10.12775/jehs.2020.10.02.041
Amin SN, Hassan SS, Khashaba AS, Youakim M, LATIF N, Rashed LA, et al. Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone. Brain Sciences [Internet]. 2020 Mar 25 [cited 2025 Nov];10(4):193. Available from: https://doi.org/10.3390/brainsci10040193
See CRZ, Tan AX, Valmaggia L, Kempton MJ. The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study. European Psychiatry [Internet]. 2025 Jan 1 [cited 2026 Jan];68(1). Available from: https://doi.org/10.1192/j.eurpsy.2025.2
Joëls M, Karst H, Krugers HJ, Lucassen PJ. Chronic stress: Implications for neuronal morphology, function and neurogenesis. Frontiers in Neuroendocrinology [Internet]. 2007 May 2 [cited 2026 Jan];28:72. Available from: https://doi.org/10.1016/j.yfrne.2007.04.001
Magariños AM, García‐Verdugo JM, McEwen BS. Chronic stress alters synaptic terminal structure in hippocampus. Proceedings of the National Academy of Sciences [Internet]. 1997 Dec 9 [cited 2025 Nov];94(25):14002. Available from: https://doi.org/10.1073/pnas.94.25.14002
Stepanenko O, Maryenko N. Structure and individual anatomical variability of the I-III lobules of the human cerebellar hemispheres. Morphologia [Internet]. 2016 Sep 16 [cited 2025 Feb];10(3):279. Available from: https://doi.org/10.26641/1997-9665.2016.3.279-282
Mundorf A, Merklein SA, Rice LC, Desmond JE, Peterburs J. Early Adversity Affects Cerebellar Structure and Function—A Systematic Review of Human and Animal Studies. Developmental Psychobiology [Internet]. 2024 Oct 8 [cited 2026 Jan];66(7). Available from: https://doi.org/10.1002/dev.22556
Cardoner N, Andero R, Cano M, Marin‐Blasco I, Porta‐Casteràs D, Serra-Blasco M, et al. Impact of Stress on Brain Morphology: Insights into StructuralBiomarkers of Stress-related Disorders. Current Neuropharmacology [Internet]. 2023 Jul 5 [cited 2026 Mar];22(5):935. Available from: https://doi.org/10.2174/1570159x21666230703091435
Radley JJ, Morilak DA, Viau V, Campeau S. Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders. Neuroscience & Biobehavioral Reviews [Internet]. Elsevier BV; 2015 Jun 24 [cited 2025 Nov];58:79. Available from: https://doi.org/10.1016/j.neubiorev.2015.06.018
Zhao N, Meng L, Zhang Y, Du G, Liu H, Gao M, et al. Microstructural alterations in gray matter after acute stress. Research Square (Research Square) [Internet]. 2024 Dec 4 [cited 2025 Aug]; Available from: https://doi.org/10.21203/rs.3.rs-5230003/v1
Kim EJ, Pellman BA, Kim JJ. Stress effects on the hippocampus: a critical review. Learning & Memory [Internet]. 2015 Aug 18 [cited 2026 Jan];22(9):411. Available from: https://doi.org/10.1101/lm.037291.114
Duller S, Clarke G, Herculano‐Houzel S, Känel R von, Kirsch P, Landolt H, et al. Everyday stress-induced neurobehavioral dysregulation: therapeutic targets for management with Neurexan. Frontiers in Psychiatry [Internet]. 2025 Oct 23 [cited 2026 Mar];16:1577689. Available from: https://doi.org/10.3389/fpsyt.2025.1577689
McEwen BS, Bowles N, Gray JD, Hill MN, Hunter R, Karatsoreos IN, et al. Mechanisms of stress in the brain. Nature Neuroscience [Internet]. 2015 Sep 25 [cited 2026 Mar];18(10):1353. Available from: https://doi.org/10.1038/nn.4086
Baek SJ, Park J, Kim J, Yamamoto Y, Tanaka K. VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors. eLife [Internet]. 2022 Feb 1 [cited 2026 Mar];11. Available from: https://doi.org/10.7554/elife.72981
Suri D, Vaidya VA. The adaptive and maladaptive continuum of stress responses – a hippocampal perspective. Reviews in the Neurosciences [Internet]. De Gruyter; 2015 Jan 1 [cited 2025 Nov];26(4):415. Available from: https://doi.org/10.1515/revneuro-2014-0083
McEwen BS, Nasca C, Gray JD. Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex. Neuropsychopharmacology [Internet]. Springer Nature; 2015 Jun 16 [cited 2025 Nov];41(1):3. Available from: https://doi.org/10.1038/npp.2015.171
Hwang K, Kim SJ, Lee Y. Cerebellar Circuits for Classical Fear Conditioning. Frontiers in Cellular Neuroscience [Internet]. 2022 Mar 30 [cited 2026 Jan];16:836948. Available from: https://doi.org/10.3389/fncel.2022.836948
Herrmann L, Ebert T, Rosén H, Novak B, Philipsen A, Touma C, et al. Analysis of the cerebellar molecular stress response led to first evidence of a role for FKBP51 in brain FKBP52 expression in mice and humans. Neurobiology of Stress [Internet]. 2021 Sep 22;15:100401. Available from: https://doi.org/10.1016/j.ynstr.2021.100401
Frankova I. Life on the brink: social stress, trauma and psychopathology. Psychosomatic Medicine and General Practice [Internet]. 2017 Jan 27 [cited 2025 Sep];2(1):20115. Available from: https://doi.org/10.26766/pmgp.v2i1.15
Rezayof A, Sardari M, Hashemizadeh S. Cellular and molecular mechanisms of stress-induced memory impairment. Exploration of neuroscience [Internet]. 2022 Dec 30 [cited 2025 Nov];100. Available from: https://doi.org/10.37349/en.2022.00008
Bender CL, Sun X, Farooq M, Yang Q, Davison C, Maroteaux M, et al. Emotional Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5–CPEB3–GluA1 Pathway. Journal of Neuroscience [Internet]. 2020 Mar 30 [cited 2025 Oct];40(17):3374. Available from: https://doi.org/10.1523/jneurosci.0013-19.2020
Chen Y, Rex CS, Rice CJ, Dubé C, Gall CM, Lynch G, et al. Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proceedings of the National Academy of Sciences [Internet]. 2010 Jul 6 [cited 2025 Aug];107(29):13123. Available from: https://doi.org/10.1073/pnas.1003825107
Ezra-Nevo G, Prestori F, Locatelli F, Soda T, Brinke MM ten, Engel M, et al. Cerebellar Learning Properties Are Modulated by the CRF Receptor. Journal of Neuroscience [Internet]. 2018 Jun 22 [cited 2026 Jan];38(30):6751. Available from: https://doi.org/10.1523/jneurosci.3106-15.2018
Harlé G. Central nervous system and immune system regulation in stress condition: role of corticoprin-releasing hormone ans its receptors. HAL (Le Centre pour la Communication Scientifique Directe) [Internet]. 2016 Sep 21 [cited 2025 Jan]; Available from: https://hal.univ-lorraine.fr/tel-01754691
Li GG, Piao CJ, Wan P, Li S, Wei YX, Zhao GJ, et al. Opposing actions of CRF-R1 and CB1 receptor on facial stimulation-induced MLI-PC plasticity in mouse cerebellar cortex. BMC Neuroscience [Internet]. 2022 Jun 26 [cited 2025 Oct];23(1). Available from: https://doi.org/10.1186/s12868-022-00726-8
Vandael D, Wierda K, Vints K, Baatsen P, Groef LD, Moons L, et al. Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress. Translational Psychiatry [Internet]. 2021 Jul 7 [cited 2026 Jan];11(1):378. Available from: https://doi.org/10.1038/s41398-021-01497-2