FARMAKOKINETIKA VA FARMAKODINAMIKANING DORILARNI ISHLAB CHIQARISHGA TA’SIRI

Xumora Abdusalomova; Shaxboz Sheravatov; Mehrinigor Rajabova; Gulyora Muxiddinova

doi:10.5281/zenodo.20812911

Авторы

Abdusalomova Xumora Abduvaqqos qizi Toshkent farmatsevtika instituti Klinik farmatsiya yo‘nalishi 4-bosqich talabasi
Sheravatov Shaxboz Yoqub o'g'li Toshkent farmatsevtika instituti Farmatsiya ishi yo‘nalishi 4-bosqich talabasi
Rajabova Mehrinigor Ravshan qizi Eksperimental va sport farmakologiyasi kafedrasi 1-bosqich magistranti
Muxiddinova Gulyora Zuxriddin qizi Toshkent farmatsevtika instituti Farmatsiya yo‘nalishi, 1-bosqich talabasi

Аннотация

Ushbu maqolada farmakokinetika va farmakodinamikaning zamonaviy dori vositalarini ishlab chiqarishdagi o‘rni, ilmiy-amaliy ahamiyati hamda dori samaradorligi va xavfsizligini ta’minlashdagi roli tahlil qilinadi. Farmakokinetika dori moddasining organizmda so‘rilishi, taqsimlanishi, metabolizmi va chiqarilishi jarayonlarini o‘rganadi. Farmakodinamika esa dori vositasining organizmga ta’sir mexanizmini, retseptorlar bilan o‘zaro aloqasini, terapevtik hamda nojo‘ya ta’sirlarini o‘rganadi. Maqolada farmakokinetik va farmakodinamik ko‘rsatkichlarning yangi dori vositalarini yaratish, optimal doza tanlash, biofoydalanish va bioekvivalentlikni baholash, klinik sinovlarni takomillashtirish hamda personalizatsiyalashgan terapiyani rivojlantirishdagi ahamiyati yoritilgan.

Ключевые слова:

farmakokinetika farmakodinamika dori ishlab chiqarish biofoydalanish metabolizm doza retseptor biologik samaradorlik xavfsizlik.

Библиографические ссылки

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FARMAKOKINETIKA VA FARMAKODINAMIKANING DORILARNI ISHLAB CHIQARISHGA TA’SIRI

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