Статьи

OSON OKSIDLANADIGAN, TERMOLABIL VA TURG'UN BO'LMAGAN MODDALAR SAQLAGAN INYEKSION ERITMALARNING XUSUSIY TEXNOLOGIYALARI

Том 4 № 56 (2026) 31-37

2026-06-09 Статьи CC BY 4.0 Open Access

Авторы

  • Sattarali Ergashevich Xaytmatov Qo‘qon universiteti Andijon filiali Biologik kimyo va farmatsevtika kafedrasi o‘qituvchi

Аннотация

Ushbu tadqiqotda oson oksidlanadigan (askorbik kislota, epinefrin, dopamin), termolabil (insulin, biologik preparatlar) va kimyoviy jihatdan turg'un bo'lmagan faol moddalar (beta-laktam antibiotiklari, nitroglitserin) saqlagan inyeksion dori shakllarini ishlab chiqishning xususiy farmatsevtik texnologiyalari tizimli tahlil qilindi. Antioksidant qo'shimchalarining (natriy metabisulfit, EDTA, tiosistein) optimal konsentratsiyalari, pH bufer tizimlari (pH 3.0–8.0), inertsiyali atmosfera (N₂, Ar) sharoitlarida ishlab chiqarish parametrlari va lyofilizatsiya rejimlarining ta'siri o'rganildi. Akseleratsiyalangan barqarorlik sinovlari (40°C/75% nisbiy namlik, 6 oy; ICH Q1A(R2) talablari) va real saqlash sharoitlari (2–8°C, 12 oy) bo'yicha olingan ma'lumotlar solishtirma tahlil qilindi. N₂ atmosferasida (O₂ < 5 ppm) qadoqlangan va 2–8°C da saqlangan namunalarda faol modda miqdorining saqlash davomida 98.6 ± 0.4% (12 oy) bo'lganligi aniqlandi, bu xona haroratida havoli sharoitda saqlangan namunadagi 91.3 ± 0.9% ko'rsatkichidan statistik jihatdan ahamiyatli darajada yuqori ekanligi ko'rsatildi (p < 0.001). Lyofilizatsiya usuli qo'llanilganda sof moddaning 12 oylik saqlash davomida 99.6 ± 0.2% gacha saqlanishi ta'minlandi. Olingan natijalar turg'unsiz moddalar uchun ishlab chiqarish texnologiyasini tanlashda ilmiy asoslangan mezonlarni belgilash imkonini beradi.

Ключевые слова:

inyeksion eritmalar oksidlanish termolabillik turg'unsizlik antioksidantlar lyofilizatsiya inertsiyali atmosfera ICH Q1A(R2) barqarorlik sinovi farmatsevtik texnologiya

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    2026-06-09

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    Том 4 № 56 (2026)

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    Sattarali, E. X. (2026). OSON OKSIDLANADIGAN, TERMOLABIL VA TURG’UN BO’LMAGAN MODDALAR SAQLAGAN INYEKSION ERITMALARNING XUSUSIY TEXNOLOGIYALARI. Наука и инновации, 4(56), 31-37. https://www.in-academy.uz/index.php/SI/article/view/51770
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