GINEKOLOGIK OPERATSIYALARDAN KEYIN OKSIDATIV STRESS VA STOKIN KASKADINING BIOXIMIK TAXLILI
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Аннотация:
Ginekologik jarrohlik amaliyotlaridan so‘ng organizmda yuzaga keladigan metabolik va molekulyar o‘zgarishlar orasida oksidativ stress va sitokin (yallig‘lanish) kaskadi yetakchi o‘rin egallaydi. Jarrohlik shikastlanishi hujayra membranalari yaxlitligining buzilishi, mitoxondrial disfunksiya va erkin radikallar hosil bo‘lishining keskin ortishi bilan kechadi. Ushbu jarayonlar lipid peroksidlanishi, oqsillar va nuklein kislotalarning oksidativ zararlanishiga olib kelib, to‘qimalarning regeneratsiya jarayonini sekinlashtiradi hamda operatsiyadan keyingi asoratlar xavfini oshiradi. Shu bilan birga, jarrohlik stressiga javoban faollashadigan sitokinlar kaskadi (IL-1β, IL-6, TNF-α va boshqalar) mahalliy va tizimli yallig‘lanish reaksiyalarini kuchaytirib, oksidativ stress bilan o‘zaro patogenetik bog‘liqlik hosil qiladi. Mazkur maqolada ginekologik operatsiyalardan keyingi oksidativ stress va sitokin kaskadining biokimyoviy mexanizmlari, ularning o‘zaro ta’siri, klinik ahamiyati hamda diagnostik va terapevtik yondashuvlar ilmiy asosda, insoniy va murakkab tahlil qilinadi. Tadqiqot natijalari operatsiyadan keyingi reabilitatsiyani optimallashtirish va asoratlarni kamaytirishda muhim ahamiyat kasb etadi.
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