The rapid proliferation of cryptocurrencies, electronic payment systems, and digital platforms has fundamentally altered the landscape of economic crime, creating novel vectors for money laundering, fraud, tax evasion, and illicit financing that challenge traditional regulatory paradigms. This article examines how digitalisation of financial flows has transformed the nature, scale, and geography of economic crime, with particular attention to the legislative responses of Uzbekistan alongside comparative analysis of approaches adopted in the European Union, the United States, the Financial Action Task Force (FATF), and South Korea. It traces the evolution of Uzbekistan's regulatory framework governing virtual assets – from the landmark Presidential Decree No. PP-4852 of 2020 to the 2022 amendments to the Anti-Money Laundering Law – and evaluates the extent to which national legislation has kept pace with rapidly morphing criminal methodologies. The article further analyses concrete statistical trends, case studies of cross-border crypto-enabled crime, and platform-facilitated financial misconduct. Findings indicate that while Uzbekistan has made substantive legislative strides, significant enforcement gaps persist, particularly in the areas of DeFi (Decentralised Finance), peer-to-peer crypto transactions, and dark-web marketplace activity. The article concludes with targeted recommendations for legislative refinement, inter-agency coordination, and international cooperation.