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ADVERSE EFFECTS OF ANEMIA IN PREGNANCY ON THE ADAPTATION PERIOD OF NEWBORNS AND THEIR HEALTHY

55 pregnant women with anemia and their children participated in the study. 20 pregnant women without anemia took part in the study as a control group.The structure of morbidity and severity of anemia of pregnant women and its consequences for fetal development and early adaptation of a newborn were investigated.The morbidity structure, the severity of anemia and the influence of mothers’ anemia to the fetuses and newborns were revealed.Iron deficiency anemia of pregnant women aggravates the course of the gestational process, causes a number of complications in childbirth and the postpartum period, affects the development of fetal and newborn pathology.It is shown that iron deficiency anemia in pregnant women is a polyethological disease with a complex pathogenesis, accompanied byiron-and folate-deficient conditions and an imbalance of the most important trace elements.

Н. А. Ахрарова

70-75

2025-03-31

ADVERSE EFFECTS OF ANEMIA IN PREGNANCY ON THE ADAPTATION PERIOD OF NEWBORNS AND THEIR HEALTHY

55 pregnant women with anemia and their children participated in the study. 20 pregnant women without anemia took part in the study as a control group.The structure of morbidity and severity of anemia of pregnant women and its consequences for fetal development and early adaptation of a newborn were investigated.The morbidity structure, the severity of anemia and the influence of mothers’ anemia to the fetuses and newborns were revealed.Iron deficiency anemia of pregnant women aggravates the course of the gestational process, causes a number of complications in childbirth and the postpartum period, affects the development of fetal and newborn pathology.It is shown that iron deficiency anemia in pregnant women is a polyethological disease with a complex pathogenesis, accompanied byiron-and folate-deficient conditions and an imbalance of the most important trace elements.

Н. А. Ахрарова

221-227

2025-03-21

RELATIONSHIP BETWEEN ANEMIA AND HAPTOGLOBIN GENOTYPE IN PATIENTS WITH RHEUMATOID ARTHRITIS

Despite the use of modern treatments for patients with RA, the incidence of anemia, unwanted complications, and disability in the working population remains very high. The purpose of the study is to improve the principles of proportional treatment, taking into account the structure of anemia in rheumatoid arthritis, its occurrence, and haptoglobin phenotypes. In 2016-2020, a total of 214 patients treated with a diagnosis of rheumatoid arthritis in the cardiorheumatology department of the Samarkand City Medical Association and 20 relatively healthy people as a control group were selected for the study. Examination of patients was carried out using generally accepted clinical, laboratory, and instrumental methods. Changes in iron metabolism parameters are observed in RA patients and are more pronounced in patients with anemia, and such changes depend on the degree of anemia.

Shodikulova Gulandon Zikiryayevna, Pulatov Ulugbek Sunatovich, Kobilov Umid Azimovich

26-32

2024-10-08

GEM SINTEZI BUZILISHINING YURAK YETISHMOVCHILIGI RIVOJLANISHIGA TA’SIRI

The association between chronic heart failure (CHF) and iron deficiency (ID) anemia is frequently observed in current medical practice and has a negative prognostic impact, reducing patients’ exercise capacity. Moreover, anemia is common in patients with chronic kidney disease (CKD) and CHF, forming an association known as cardio-renal anemia syndrome (CRAS), which significantly increases the risk of mortality. This article aims to present the impact of ID in CHF patients and the benefits of iron supplementation in CHF, based on the relationship between functional and absolute ID in CHF. A complex pathophysiological interaction is described, including decreased erythropoietin levels and activation of the renin-angiotensin-aldosterone system. These mechanisms exacerbate anemia, CHF, and CKD, worsening patient outcomes.

Alisher Shuxratov

276-280

2025-02-20

PROPER DIAGNOSIS OF THE DISEASE AND FURTHER TREATMENT OF B12-DEFICIENCY ANEMIA

In 12-deficiency anemia, the syndrome of damage to the nervous system dominates, which naturally forces them to seek help from a neurologist. In these cases, the correct diagnosis of the disease and further treatment depend on the latter, since the hasty administration of vitamin B12 very quickly leads to the disappearance of megaloblasts from the bone marrow, which are a pathognomonic sign of percinous anemia. This makes it difficult to recognize the true nature of neurological disorders. Unfortunately, it should be recognized that to date, the neurological manifestations of B12-deficiency anemia have not been systematized and do not have a clear description.

Hasanov Alisher Yurievich, Khakimova Sohiba Ziyadulloevna

101-103

2024-10-07

PHARMACEUTICAL TABLET MANUFACTURING PROCESS VIA WET GRANULATION FOR IRON DEFICIENCY ANEMIA TREATMENT ERITIM

The most prevalent form of nutritional deficiency resulting in anemia is iron deficiency, primarily caused by insufficient consumption of dietary iron. World Health Organizations’ information indicate that, 40% of all children aged 6–59 months, 37% of pregnant women and 30% of women 15–49 years of age are suffer from anaemia. Anemia is most commonly found in children under the age of 5, especially infants and those under 2 years old. These young children are particularly vulnerable to developing anemia [1].

Shukhrat Makhmadaliyevich Turaboev

79-80

2025-02-24

ANALYSIS OF THE PREVALENCE OF IRON DEFICIENCY ANEMIA AND THE PHARMACOLOGICAL PROPERTIES OF DRUGS USED FOR THEIR TREATMENT

About one in four people worldwide suffer from iron ID, the most common micronutrient deficiency. Children, women of reproductive age, and those living in low- and middle-income nations are disproportionately affected. With effects ranging from decreased physical performance and quality of life in adults to increased risks during pregnancy, including low birth weight, preterm delivery, and maternal mortality, as well as impaired cognitive and motor development in children, it substantially adds to the global burden of disease. Though clinical and functional abnormalities, including exhaustion, immunological dysfunction, and cognitive deficiencies, can happen even in the absence of anemia, ID frequently occurs before IDA. According to the World Health Organization, iron deficiency anemia (IDA) affects 30% of the population worldwide, making it the most prevalent dietary deficiency. Reduced dietary iron and decreased iron absorption are additional contributing factors to IDA, even though gastrointestinal bleeding and women's menstruation are the most frequent causes. Restoring iron reserves and bringing hemoglobin levels back to normal should be the goals of treatment for patients with IDA. This has been demonstrated to enhance pregnancy outcomes, morbidity, quality of life, and the prognosis for chronic illnesses. Numerous chronic inflammatory diseases, such as inflammatory bowel disease, chronic kidney disease, and congestive heart failure, are associated with iron deficiency. An updated summary of the diagnosis and treatment of IDA in patients with chronic illnesses, both before and during pregnancy, will be given in this article. Along with a summary of the cost comparison of the various iron formulations now available on the market, we will go over the advantages and disadvantages of oral versus intravenous iron replacement in each group. 

Sokhib Rashidov Zamon ugli, Abrorbek Pirmanov Akbarali ugli

43-50

2026-02-12

HEMOSTATIC CHANGES IN ACTIVE OF DESTRUCTION IN TUBERCULOSIS

Analysis in patients with active PTB showed anemia, leucocytosis, thrombocytosis, elevation in plasma fibrinogen, factor VIII, plasminogen activator inhibitor 1 (PAI-1) with depressed antithrombin III (AT III) and protein C (PC) levels. On the 30th day of treatment, anemia, leucocytosis and thrombocytosis were improved. With the development of tuberculosis against the background of pronounced immunodeficiency and the predominance of the exudative nature of inflammation with damage to the microhemocirculatory bed of the lungs, a significant deposition of fibrin in the inflammatory zone becomes possible. On the 30th day of treatment, anemia, leucocytosis and thrombocytosis were improved. Fibrinogen and factor VIII levels had decreased to normal levels, PC and AT III levels had increased to normal levels, and there was no difference in PAI-1 levels. We found no activated protein C resistance. Platelet aggregation studies demonstrated increased platelet activation. However, DVT was not detected in patients during the follow-up period.

Alimova Gulrukh Salimovna

34-38

2023-12-15

RATIONAL USE OF IRON SUPPLEMENTS IN THE TREATMENT OF ANEMIA

Anemia remains one of the most common pathologies in clinical practice and represents a significant medical and social problem affecting various age and clinical groups. Iron deficiency is the leading cause of anemic conditions in many cases, leading to the widespread use of iron supplements for therapeutic and prophylactic purposes

М.И. Мухитдинова

195-202

2026-01-26

SEVERE VITAMIN B12–DEFICIENCY ANEMIA: LABORATORY FINDINGS AND DIAGNOSTIC RELEVANCE

Severe vitamin B12–deficiency anemia is a major hematologic disorder marked by impaired DNA synthesis, ineffective erythropoiesis, and macrocytic transformation of erythroid precursors. Despite its clinical importance, comparative laboratory data for severe B12 deficiency remain limited. This study aimed to characterize key hematological abnormalities and assess the diagnostic utility of serum vitamin B12 in adults with severe deficiency.

Нозима Абдуллаева

68-74

2025-12-24

THYROID HORMONE DEFICIENCY AS A CAUSE OF ANEMIA

Anemia is a clinical and hematological condition characterized by a decrease in hemoglobin levels in the peripheral blood, leading to insufficient oxygen transport to tissues and organs. It can result from various underlying causes, including nutritional deficiencies, chronic diseases, genetic disorders, and hormonal imbalances. One of the factors that have been shown to influence the development of anemia is thyroid hormone deficiency.

Khaydarov Sanjar Nizamitdinovich

27-28

2025-03-14

INFORMATION ABOUT THE LEVEL I OF ANEMIA DISEASE

This article studied patients with IDA, determined the mild degree of the disease in children and highlighted the general condition of the examined patients. It is explained that it causes anemia, gastrointestinal tract problems, rickets, and frequent colds.

Asrorov Akmal Aminjonovich

224-229

2024-05-29

FOLIC ACID DEFICIENCY AND ITS SIGNIFICANCE: PATHOGENESIS, CLINICAL OUTCOMES, RISK FACTORS, EPIDEMIOLOGICAL SITUATION AND PREVENTIVE STRATEGIES

This article provides an in-depth analysis of the biochemical and physiological roles of folic acid (vitamin B9), focusing on DNA and RNA synthesis, cell division, methylation reactions, hematopoiesis, and embryonic development. The pathophysiological mechanisms of folate deficiency, global and regional epidemiological indicators, and clinical outcomes—including megaloblastic anemia, neural tube defects, cardiovascular diseases, depression, and cognitive impairment—are examined based on evidence-based data. Risk groups, folate requirements during pregnancy, the consequences of micronutrient deficiency, and the effectiveness of fortification programs are evaluated. The findings confirm that adequate folic acid intake is a crucial determinant for perinatal health, prevention of neonatal disabilities, and reduction of hematological and cardiometabolic risks.

Mehribon Xujamuratova, Yangildi Ximmatova

51-57

2025-11-30

IMPORTANCE OF SOYBEAN PLANT IN MEDICINE

the article describes the role and importance of high-quality soybeans in human life in our country, the use of soybeans in the treatment of diseases such as anemia, cancer, diabetes, kidney stones, cirrhosis of the liver.

Aminjonova Charoskhan Akmalovna

219-223

2024-05-29

DEVELOPMENT OF A TECHNOLOGY FOR PREPARING A FOOD BASED ON ANTI-ANEMIA FOOD

This article presents the results of research on the development of a syrup preparation technology based on plant raw materials with anti-anemic properties. The aim was to select biologically active components of plant origin, containing iron, vitamins and organic acids, which have the property of stimulating hematopoiesis processes. A technological scheme for syrup production was developed, its physicochemical, organoleptic and microbiological properties were evaluated. The possibilities of using the developed product as a functional food product and auxiliary agent in the prevention and complex treatment of anemia were demonstrated.

Tashmuxamedova M.A., Fayzullaeva N.S., Mamatova K.M.

175-178

2026-01-22

ANALYSIS OF IRON MICROELEMENTS AMOUNT IN THE GRAIN OF ANCIENT WHEAT VARIETIES

The amount of microelement - iron, important for human health, has been screened in the grain of wheat varieties that have been planted in Uzbekistan for a long time. As a result of the screening, samples with a relatively high content of iron microelement were isolated, and research is being carried out on indicators such as cultivation technology, biochemical indicators and resistance to unfavorable factors in conditions of grassland alluvial soils of the Khorezm Oasis.

Isaeva Zakhro

299-302

2024-03-31

RESEARCHING THE EFFECT OF IRON DEFICIENCY ANEMIA ON THE RESILIENCE OF THE COLLECTIVE COLLECTED BASED ON PERENNIAL PLANTS (NETTLE, DOG ROSE, HAWTHORN) OBTAINED.

Researching the effect of iron deficiency anemia on the resilience of the collective collected based on perennial plants (nettle, dog rose, hawthorn) obtained.

A.J.Rajapov, Kh.O.Darmanov

324-325

2024-06-30

MODERN METHODS OF PREVENTING IRON DEFICIENCY IN WOMEN AND CHILDREN

This article scientifically substantiates and draws conclusions on modern methods of prevention of iron deficiency anemia in women and children living in the districts of Tashkent region.

Almardonova Zulxumor Jalilovna, Djuraeva Muhabbat Ergashovna

263-267

2022-10-18

MODERN METHODS OF PREVENTING IRON DEFICIENCY IN WOMEN AND CHILDREN

This article scientifically substantiates and draws conclusions on modern methods of prevention of iron deficiency anemia in women and children living in the districts of Tashkent region.

M.A Saitmuratov, B.H. Shermatov, S.E. Xudoyberdiev

444-449

2022-02-18

FEATURES OF THE WITHDRAWAL OF RHEUMATOID ARTHRITIS IN PATIENTS WITH LOW HEMOGLOBIN LEVELS

This work presents the results of an examination of 37 patients (ages 26 to 64) with low hemoglobin rheumatoid arthritis (RA). Of the 14 patients (37.8%) we observed (Group 1), reliable low hemoglobin values (<110 g/l) were reported, while the remaining 23 (62.2%) Patients (Group 2) had normal hemoglobin levels.

Nafisa Xodjiyeva , Dilbar Djalolova, Komila Abdushukurova , Suxrobjon Kazimov

85-90

2025-11-30

IRON DEFICIENCY ANEMIA I DEGREE

This article studied patients with IDA, determined the mild degree of the disease in children and highlighted the general condition of the examined patients. It is explained that it causes anemia, gastrointestinal tract problems, rickets, and frequent colds.

Asrorov Akmal Aminjonovich

70-76

2023-12-09

GENERAL BLOOD ANALYSIS: CLINICAL AND DIAGNOSTIC SIGNIFICANCE IN MODERN LABORATORY MEDICINE

General blood analysis (complete blood count, CBC) is one of the most widely used laboratory diagnostic tests in modern clinical practice. It provides essential information about the physiological and pathological conditions of the human body. This article discusses the clinical and diagnostic significance of general blood analysis, including the evaluation of hemoglobin levels, erythrocytes, leukocytes, platelets, hematocrit, and erythrocyte indices. Changes in hematological parameters in conditions such as anemia, inflammatory diseases, infectious disorders, allergic reactions, and hematological malignancies are analyzed. The role of automated hematology analyzers in improving diagnostic accuracy and efficiency is also examined. The findings indicate that general blood analysis remains a fundamental and highly informative tool for early disease detection, monitoring of treatment effectiveness, and preventive medical examinations.

Ayjan Karimova

8-14

2026-02-17

INFORMATION ABOUT THE LEVEL III OF ANEMIA DISEASE

This article studied patients with IDA, determined the mild degree of the disease in children and highlighted the general condition of the examined patients. It is explained that it causes anemia, gastrointestinal tract problems, rickets, and frequent colds.

Asrorov Akmal Aminjonovich

230-235

2024-05-29

IRON DEFICIENCY ANEMIA III DEGREE

This article studied patients with IDA, determined the mild degree of the disease in children and highlighted the general condition of the examined patients. It is explained that it causes anemia, gastrointestinal tract problems, rickets, and frequent colds.

Asrorov Akmal Aminjonovich

77-83

2023-12-09

STUDY OF VITAMIN COMPOSITION OF DRY EXTRACT OBTAINED BASED ON VARIOUS SOLVENTS FROM LEAVES OF OFFICINAL SAGE – SАLVIA OFFICINАLIS L., CULTIVATED IN UZBEKISTAN

The paper presents the results of a study of the vitamin composition of a dry extract obtained on the basis of various solvents (80% ethanol, butanol) from the leaves of medicinal sage - Salvia officinalis L., cultivated in Uzbekistan. The samples were found to contain vitamins С, В1, В2, В3, В6, В9, which play an important role in the body. Among them, the most quantitatively dominant are riboflavin (B2) and folic acid (B9), the deficiency of which can cause a deterioration in the general condition of the body, depression, deterioration of the nervous system, as well as dry skin, burning eyes and photosensitivity, anemia, fatigue and irritability. The obtained data will be in demand for the chemical characterization of dry extracts and their subsequent standardization.

Normakhamatov Nodirali Sokhobatalievich, Mullazhonova Manzura Tokhirovna, Turaboev Abdulkhamid Abduvohid ugli

69-72

2025-04-08

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