The effect of pregnancy on the clinical course and prognosis in delanomas is the subject of contradictory observations and conclusions. There are known data on the effect of certain hormones on the pigment system and the relationship between sex hormones and malignant melanoma. It was found that there are special receptors for estrogens in the cytoplasm of primary melanoma cells (Bruli S., 2010). In the United States, it is possible to determine to what extent this is the case (Sadoff L. and others, 2013; Lerner L. et al., 2019). However, A.Adam. (2011) did not find a link between the use of hormonal contraceptives and the occurrence of melanoma. To.Sutherland. (2013) indicate an increase in hormone levels during pregnancy, and then a rapid decrease after childbirth.