Candidiasis, which occurs in people with weakened immune systems, is the most common fungal infection in patients diagnosed with HIV, which worsens the course of the disease and negatively affects the quality and life expectancy of patients. This infection mainly affects the skin and mucous membranes of organs and systems, causing severe peeling, which is often found in an invasive form. This infection, which develops in more than 90% of HIV-infected people, is more pronounced in the pre-active art and later stages of AIDS. In this review, the main task is to analyze the epidemiology of candidiasis that has developed against the background of HIV, and the relevance of its detection and the specifics of its control. It is known that the development of candidiasis is caused by several Candida species, and the identification of each pathogen causing candidiasis at the molecular level is considered important.