ANTIBIOTIC RESISTANCE AND ANATOMICAL-FUNCTIONAL FACTORS IN THE PREVENTION OF RECURRENT URINARY TRACT INFECTIONS
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Аннотация:
Recurrent urinary tract infections (rUTIs) constitute a major clinical challenge due to their high prevalence, impact on quality of life, and increasing association with antibiotic-resistant pathogens. The frequent use of antimicrobial agents has contributed to the emergence of multidrug-resistant uropathogens, complicating both treatment and prevention strategies. In addition to microbial factors, anatomical and functional abnormalities of the urinary tract play a crucial role in the persistence and recurrence of infections. This review provides an in-depth analysis of antibiotic resistance mechanisms in uropathogens and examines the contribution of anatomical and functional factors to recurrent UTIs. Furthermore, it discusses current diagnostic approaches and emphasizes integrated preventive strategies, including non-antibiotic measures and correction of underlying abnormalities. A comprehensive understanding of these factors is essential for developing effective, sustainable prevention strategies and reducing the global burden of recurrent UTIs.
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Библиографические ссылки:
Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med. 2002;113(Suppl 1A):5S–13S.
Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015;13(5):269–284.
Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis. Clin Infect Dis. 2011;52(5):e103–e120.
Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Dis Mon. 2003;49(2):71–82.
Nicolle LE. Urinary tract infection in adults. Lancet. 2008;371(9624):1572–1581.
Stamm WE, Norrby SR. Urinary tract infections: disease panorama and challenges. J Infect Dis. 2001;183(Suppl 1):S1–S4.
Hooton TM. Recurrent urinary tract infection in women. Int J Antimicrob Agents. 2001;17(4):259–268.
Wagenlehner FME, Naber KG. Treatment of bacterial urinary tract infections: presence and future. Eur Urol. 2006;49(2):235–244.
Sanchez GV, Master RN, Karlowsky JA, Bordon JM. In vitro antimicrobial resistance of urinary E. coli isolates. Antimicrob Agents Chemother. 2012;56(4):2181–2183.
Grigoryan L, Trautner BW, Gupta K. Diagnosis and management of urinary tract infections in the outpatient setting. JAMA. 2014;312(16):1677–1684.

