ANTI-INFLAMMATORY PROPERTIES OF GERMAN CHAMOMILE: CHEMICAL COMPOSITION AND MOLECULAR MECHANISMS
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Abstract:
German chamomile (Matricaria chamomilla L.) is among the most widely used medicinal plants with well-documented anti-inflammatory activity. This review article, for the first time, provides a comprehensive and systematized analysis of current data on the pharmacological and anti-inflammatory properties of German chamomile from the perspective of the relationship between its chemical composition and the molecular mechanisms of inflammation. It is demonstrated that flavonoids, sesquiterpene compounds, and phenolic acids of the plant are capable of modulating the activity of pro-inflammatory mediators, inflammatory enzyme systems, and oxidative stress. Special attention is given to studies conducted by Uzbek researchers, which form the scientific and raw material basis for the development of phytopharmaceuticals based on German chamomile. The results of this review may be used for the standardization of medicinal plant raw materials and the development of anti-inflammatory phytomedicines.
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Абдуллаева Н.Ф., Каримова Д.А. Фармакогностическая характеристика цветков ромашки аптечной Фармацевтический журнал Узбекистана, 2019, № 3, с. 45–49.
Ибрагимова Д.М., Рахматуллаева Н.Т. Качество лекарственного растительного сырья ромашки аптечной Инфекция, иммунитет и фармакология, 2021, № 2, с. 62–67.
Худайбердиева Ш.Р. Фармакологическая активность экстрактов Matricaria chamomilla L.: диссертация. Ташкент, 2020, с. 1–120.
El Mihyaoui A., Charfi S., Lakhal F., et al. Chamomile (Matricaria chamomilla L.): phytochemistry and pharmacology Life, 2022, Vol. 12, Article 479, pp. 1–18.
Khan S., Patel D., Waghmare S., et al. Apigenin and inflammatory pathways Molecular Medicine Reports, 2021, Vol. 24, pp. 1–10.
Li J., Chen S., Lan W. Pharmacological effects of Matricaria chamomilla Chinese Pharmaceutical Journal, 2024, Vol. 59, pp. 742–749.
Sepp J., Kunnapas A., Vaher M., et al. Galenic dry extracts of German chamomile
Plants, 2024, Vol. 13, Article 350, pp. 1–14.
Valmy J., Martin C., Lefèvre G., et al. Anti-inflammatory effect of chamomile
Pharmaceutical Biology, 2025, Vol. 63, pp. 1–12.
Zielińska S., Matkowski A. Rosmarinic acid and its pharmacological potential
Phytochemistry Reviews, 2021, Vol. 20, pp. 459–474.
Srivastava J.K., Shankar E., Gupta S. Chamomile: a herbal medicine of the past with bright future Molecular Medicine Reports, 2020, Vol. 22, pp. 1–8.
McKay D.L., Blumberg J.B. Bioactivity and potential health benefits of chamomile teaPhytotherapy Research, 2018, Vol. 32, pp. 451–466.
Anderson L.A., Phillipson J.D. Anti-inflammatory mechanisms of medicinal plants
Journal of Herbal Medicine, 2019, Vol. 18, pp. 100–110.