ADAPTATION MECHANISMS OF KUPPFFER CELLS

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Issue: Vol. 5 No. 11 Part 2 : Eurasian Journal of Academic Research
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Toshkent Davlat Tibbiyot Universiteti Normal va patologik fiziologiya kafedrasi assistenti
info@in-academy.uz
Toshkent Davlat Tibbiyot Universiteti 1-davolash fakulteti 2-kurs talabalari
info@in-academy.uz
Toshkent Davlat Tibbiyot Universiteti 1-davolash fakulteti 2-kurs talabalari
info@in-academy.uz
Toshkent Davlat Tibbiyot Universiteti 1-davolash fakulteti 2-kurs talabalari
info@in-academy.uz

Abstract:

Kupffer cells (KCs) are specialized tissue macrophages located in the liver parenchyma that act as the first line of immune response to protect the body from toxic, microbiological, and metabolic stresses. Genomic, transcriptomic, and metabolomic studies conducted over the past decade have shed light on the mechanisms by which KCs adapt to variable microatrophy. These cells exhibit phenotypic plasticity depending on the intrahepatic oxygen pressure gradient, nutrient concentration, and levels of endogenous signaling molecules.

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How to Cite:

Xalilov , H., Joʻrayeva , S., Axmedova , S., & Fayziyeva , S. (2025). ADAPTATION MECHANISMS OF KUPPFFER CELLS. Eurasian Journal of Academic Research, 5(11 Part 2), 29–38. Retrieved from https://www.in-academy.uz/index.php/ejar/article/view/67412

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